Copaiba (Copaifera reticulata) oleoresin reduces voluntary alcohol intake in rats

ABSTRACT Copaiba oleoresin, extracted from the Copaifera reticulata tree, has been used as a remedy in popular medicine Brazilian Amazon for various purposes, including reducing drug abuse. Yet no studies evaluated effect of repeated administration copaiba oil on alcohol consumption animals. To evaluate this effect, we divided adult male Wistar rats into a) an group which animals had free access to choose between two bottles: one containing solution (20%) and another vehicle (0.2% saccharin); b) control with bottles solution. Rats were drink 24 h per day, 35 days. Daily weekly body weight gain food intake monitored. From day 22, half each received 600 mg kg-1 oleoresin other vehicle, subcutaneously, once three On 35, open-field test. The results showed that decreased voluntary preference days 2 6 after last administration. treatment also both groups without changing behaviors Therefore, was able reduce could be tested humans adjuvant treat use disorder.